ABSTRACT
The clinical data of 10 patients with prostate abscess admitted to our hospital were retrospectively analyzed. Summarize its diagnosis and treatment characteristics and its clinical efficacy. Prostatic abscess can generally be effectively controlled by timely, adequate and effective antibiotic treatment and active control of comorbidities. Prostate abscess deroofing might be an effective treatment for patients with the failure of conservative antibiotic treatment.
ABSTRACT
Objective@#To investigate the epidemiological characteristics and its associated risk factors of lower urinary tract symptoms in young Chinese obese males.@*Methods@#A total of 126 young males aged 20-40 years admitted to Beijing Friendship Hospital, Capital Medical University were enrolled into two different groups in this study, including 74 obese patients visited metabolic weight loss clinic were included in the experimental group, and 52 conditionally healthy persons were included in the control group. Blood pressure (systolic blood pressure, diastolic blood pressure), insulin resistance (fasting blood glucose, insulin, C-peptide), blood lipid metabolism (triglycerides, high-density lipoprotein cholesterol), and sex hormones (estrogen) of the two groups of subjects. Hormones, serum testosterone), C-reactive protein (CRP), International prostate symptom score (IPSS) and quality of life score (QOL). were compared between the two groups of subjects. Comparisons of measurement data between groups were statistically analyze by t test, expressed by mean ± standard deviation (Mean±SD); the correlation between body mass index and LUTS was analyzed by Spearman rank correlation, and the risk factors of LUTS and clinical variables were analyzed by univariate logistic regression. The significant variables were analyzed by multivariate logistic regression.@*Results@#There were significant statistical differences between experimental group and control group in terms of systolic blood pressure [(144.30±15.78) mmHg vs (125.9±66.11) mmHg, P<0.001], diastolic blood pressure [(89.46±12.76) mmHg vs (81.35±4.58) mmHg, P=0.001], and fasting blood glucose [(6.73±3.15) mmol/L vs (5.26±1.47) mmol/L, P=0.016], insulin [(26.60±19.09) mg/dL vs (13.43±7.68) mg/dL, P<0.001], C-peptide [(4.20±1.73) ng/mL vs (1.59±0.52) ng/mL, P=0.001], triglycerides [(2.42±1.88) mg/dL vs (1.45±0.79) mg/dL, P=0.007), estrogen [(52.32±21.77) ng/L vs (42.11±12.19) ng/L, P=0.023] and CRP [(6.49±4.96) mg/L vs (1.62±1.53) mg/L, P=0.037], but no statistical difference regarding high-density lipoprotein [(1.10±0.55) mg/dL vs (1.06±0.26) mg/dL, P=0.669] and serum testosterone [(275.00±100.68) ng/dL vs (280.28±85.52) ng/dL, P=0.823]. In addition, the experimental group had higher IPSS[(3.81±1.88) scores vs (0.69±0.30) scores, P<0.001] and QOL scores [(2.76±0.68) scores vs (0.12±0.08) scores, P<0.001] than the control group, and higher risk of LUTS [86.49% vs 42.31%, P<0.001], especially moderate LUTS ( 21.62% vs 0, P=0.011). Spearman rank correlation analysis showed that obesity (body mass index≥30 kg/m2) was significantly associated with moderate LUTS risk (r=0.407, P<0.001); Univariate logistic regression analysis showed that systolic blood pressure, insulin, and C-peptide were important risk factors of moderate LUTS in young obese patients (P=0.009, 0.029, 0.002). Systolic blood pressure and fasting C-peptide were independent risk factors by multivariate logistic regression analysis (P=0.011, 0.003).@*Conclusions@#The middle severity of LUTS was prevalent in young obese males, and systolic blood pressure and C-peptide were its significant independent risk factors.
ABSTRACT
Objective:To analyze the risk factors of stress urinary incontinence after transurethral enucleation of prostate.Methods:A retrospective analysis of the clinical data of 326 patients who underwent transurethral enucleation of prostate at the Beijing Friendship Hospital, Capital Medical University due to benign prostatic hyperplasia from March 2016 to December 2019. Patients were divided into stress urinary incontinence group ( n=78) and non-stress urinary incontinence group ( n=248) according to whether there was stress urinary incontinence one week after the catheter was removed. Age, body mass index, hypertension, diabetes, hyperlipidemia, prostate volume, the time of lower urinary tract symptoms (LUTS), total prostate specific antigen, preoperative indwelling catheter status, operation type, operation time, percentage of hemoglobin reduction and catherization time were compared between the two groups. Measurement data were expressed as mean±standard deviation ( Mean± SD), and t-test was used for comparison between groups; Chi-square test or Fisher exact probability method was used for comparison of count data between groups. Single factor and multivariate Logistic regression analysis were used to screen independent predictors. Results:Age [(73.9±7.3) years vs (69.5±7.8) years, P<0.001], body mass index [(25.6±3.0) kg/m 2vs (24.6±2.9) kg/m 2, P=0.004], the time of LUTS [(5.42±5.65) years vs (5.05±5.19) years, P=0.008], and hypertension (57.7% vs 43.6%, P=0.037), prostate volume [(77.1±33.2) mL vs (62.5±30.2) mL, P<0.001], operation time [(115.0±45.7) min vs (99.8±41.4) min, P=0.006] in stress urinary incontinence group were significantly higher than those in the non-stress urinary incontinence group, the differences were statistically significant. Age ( OR=1.05, 95% CI: 1.02-1.07, P<0.001), body mass index ( OR=1.08, 95% CI: 1.03-1.14, P=0.003), LUTS ( OR=1.21, 95% CI: 1.14-1.29, P=0.015)and prostate volume ( OR=1.11, 95% CI: 1.10-1.11, P=0.011) were independent risk factors for stress urinary incontinence after transurethral enucleation of prostate by multivariate Logistic regression analysis. Conclusion:Age≥70years, body mass index≥25 kg/m 2, LUTS during≥5 years and prostate volume≥75 mL are independent risk factors for stress urinary incontinence after transurethral enucleation of prostate.
ABSTRACT
Objective To investigate the epidemiological characteristics and its associated risk factors of lower urinary tract symptoms in young Chinese obese males.Methods A total of 126 young males aged 20-40 years admitted to Beijing Friendship Hospital,Capital Medical University were enrolled into two different groups in this study,including 74 obese patients visited metabolic weight loss clinic were included in the experimental group,and 52 conditionally healthy persons were included in the control group.Blood pressure (systolic blood pressure,diastolic blood pressure),insulin resistance (fasting blood glucose,insulin,C-peptide),blood lipid metabolism (triglycerides,high-density lipoprotein cholesterol),and sex hormones (estrogen) of the two groups of subjects.Hormones,serum testosterone),C-reactive protein (CRP),International prostate symptom score (IPSS) and quality of life score (QOL).were compared between the two groups of subjects.Comparisons of measurement data between groups were statistically analyze by t test,expressed by mean ± standard deviation (Mean ± SD);the correlation between body mass index and LUTS was analyzed by Spearman rank correlation,and the risk factors of LUTS and clinical variables were analyzed by univariate logistic regression.The significant variables were analyzed by multivariate logistic regression.Results There were significant statistical differences between experimental group and control group in terms of systolic blood pressure [(144.30 ± 15.78) mmHg vs (125.9 ±66.11) mmHg,P＜0.001],diastolic blood pressure [(89.46 ± 12.76) mmHg vs (81.35 ±4.58) mmHg,P =0.001],and fasting blood glucose [(6.73 ± 3.15) mmol/L vs (5.26 ± 1.47) mmol/L,P =0.016],insulin [(26.60 ± 19.09) mg/dLvs (13.43 ±7.68) mg/dL,P＜0.001],C-peptide [(4.20±1.73) ng/mL vs (1.59 ± 0.52) ng/mL,P=0.001],triglycerides [(2.42 ± 1.88) mg/dL vs (1.45 ± 0.79) mg/dL,P =0.007),estrogen [(52.32±21.77) ng/L vs (42.11 ± 12.19) ng/L,P =0.023] and CRP [(6.49±4.96) mg/L vs (1.62 ±1.53) mg/L,P =0.037],but no statistical difference regarding high-density lipoprotein [(1.10 ± 0.55) mg/dL vs (1.06 ±0.26) mg/dL,P =0.669] and serum testosterone [(275.00 ± 100.68) ng/dL vs (280.28 ± 85.52) ng/dL,P =0.823].In addition,the experimental group had higher IPSS [(3.81 ± 1.88)scores vs (0.69 ±0.30) scores,P ＜0.001] and QOL scores [(2.76 ±0.68) scores vs (0.12 ±0.08) scores,P＜0.001] than the control group,and higher risk of LUTS [86.49％ vs 42.31％,P ＜ 0.001],especially moderate LUTS (21.62％ vs 0,P =0.011).Spearman rank correlation analysis showed that obesity (body mass index≥30 kg/m2) was significantly associated with moderate LUTS risk (r =0.407,P ＜ 0.001);Univariate logistic regression analysis showed that systolic blood pressure,insulin,and C-peptide were important risk factors of moderate LUTS in young obese patients (P =0.009,0.029,0.002).Systolic blood pressure and fasting C-peptide were independent risk factors by multivariate logistic regression analysis (P =0.011,0.003).Conclusions The middle severity of LUTS was prevalent in young obese males,and systolic blood pressure and C-peptide were its significant independent risk factors.
ABSTRACT
Objective To summarize the clinical experience of combined single-access minimally invasive percutaneous nephrolithotomy (MPCNL) and lithotripsy through flexible ureteroscope in the treatment of staghorn calculi.Methods Fifty-seven cases of renal staghom calculi underwent combined MPCNL and lithotripsy through flexible ureteroscope.The size of calculi was (2.7 cm×3.3 cm-3.8 cm × 5.2 cm),3.7 cm×4.1 cmon average.Results The success rate of stone fragmentation was 80.7% (46/57) after the first stage of operation,duration of which was 128 min on average.The average loss of blood was 80 mL (20 - 150 mL).Eleven patients with residual calculi in the middle and lower calyx were also underwent the second stage of operation after 5 - 7 days.The average operation duration of the second stage was 57 min and the total clearance rate was 93% (53/57).Four cases had a few of residual calculi with size of 0.4 - 0.8 cm and went on with the treatment of extracorporeal shock wave lithotripsy(ESWL).Two cases were stone-free in the follow-up for 3 months.Conclusion MPCNL combined with with lithotripsy through flexible ureteroscope on the treatment of staghom calculi can decrease the therapeutic risk and complication,increase the rate of stone-free and safety.
ABSTRACT
Interleukin-22 (IL-22) is a new kind of eytokine discovered in 2000. The major sources of IL-22 are activated T1 -cells and NK-cells. Tissue cells at outer body barriers, i.e. of the skin, kidney, the di-gestive and respiratory systems all highly express IL-22R or respond to IL-22. IL-22 functions by promoting the anti-microbial defense, inducing phase reactants, protecting against damage and enhancing natural immu-nity. Furthermore, IL-22 mediates the proliferation, differentiation and apoptesis in cancer cells, that gives us a new idea about tumor therapy.